Our paper, entitled “Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains” (Roelle et al), is published in PLoS Biology!

New preprint! SARS-like CoVs sequenced from bats in Europe and Africa use various horseshoe bat ACE2s for entry. Viruses found in Russia and Kenya also have the ability to at least weakly use human ACE2. Molecular insights for understanding zoonosis. 1/3https://t.co/gkIfSYtXFO

— Kenneth Matreyek (@kmatreyek) December 29, 2021

Now published in @PLOSBiology! (https://t.co/Yhibhfwkao) IMO, the coolest new data is Fig 7D, where we toggle RBD compatibility with human ACE2 by introducing Q or K amino acids in BtKY72 or Khosta2 RBDs at the residue across from ACE2 K31. Parallels to original SARS adaptation! https://t.co/d3OFFplye1 pic.twitter.com/4X2UxmujCr

— Kenneth Matreyek (@kmatreyek) July 27, 2022

Which viruses are primed for #zoonotic transmission? @kmatreyek &co show that SARS-like bat #coronaviruses from Europe & Africa can use a range of horseshoe bat ACE2s for entry; some viruses from Russia & Kenya can also (weakly) use human ACE2 #PLOSBiology https://t.co/3Fgxzy4PKe pic.twitter.com/U22glsGfOC

— PLOS Biology (@PLOSBiology) August 2, 2022